| Date |
Title |
Abstract / Details |
Download options |
| January 2010 |
Atmospheric Spray Freeze Drying: A New Approach |
The ASFD process has been developed as a new method for manufacturing powder. The goal was to
reduce drying time and operate atmospheric conditions with reasonable collection efficiency. |
PDF, 289KB
Download.
|
| November 2009 |
White Paper: Using Laser-Based Headspace Moisture Analysis for Rapid Nondestructive Moisture
Determination of Sterile Freeze-Dried Product |
Residual product moisture content is a critical parameter when considering stability and shelf
life of lyophilized product. Traditional moisture analysis includes Karl Fischer or TGA methods. Replacing these
methods with a rapid non-destructive method would streamline moisture analysus and improve the quality of the
finished product. |
PDF, 2.2MB
Download.
|
| November 2009 |
A study of vial headspace moisture in an entire freeze dried batch and the factors affecting
moisture content variability. |
The moisture content within a freeze dried material has a direct effect on long term stability
and storage temperature. Estabilshing moisture content uniformity is an important quality control tool. |
Presentation in PDF format, 422KB
Download.
|
| April 2009 |
Why, What, How - Understanding the Freeze Drying Process |
An overview of the freeze-drying process, designed for those with little or not experience of
the process. This article also looks at the importance of critical temperatures in formulation and cycle design. |
PDF, 208KB Download.
|
| August 2008 |
Freeze-Dried Cakes - Where is the Water? |
Frequency Modulation Spectroscopy is a relatively new technique that measures the
moisture and pressure in the vial headspace. The aim of the study is to understand the relationship between the moisture analysed
by Karl Fischer and Frequency Modulation Spectroscopy and further our understanding of product-water interactions within a
freeze dried cake.
This study was carried out in collaboration with Lighthouse Instruments - visit their website
here. |
PDF, 2.5MB Download.
|
August 2008 |
The Use of Impedance Analysis for the Study of Critical Events in the Frozen State, for Formulation
and Lyo-Cycle Development |
Lyotherm2 was employed to analyse a wide range of simple solutions and more complex formulations prior
to freeze-drying in order to establish whether the measurement of Zsinφ can provide meaningful information that other
techniques may be unable to detect. Carried out in collaboration with NIBSC - visit their site
here |
PDF 1.2MB. Download.
|
January 2008 |
The Importance of Critical Temperatures in the Freeze Drying of Pharmaceutical Products |
Every formulation will have a critical temperature, below which it should be cooled in order to
minimise processing defects. Therefore in order to design freeze drying cycles on a rational, product-specific basis,
such information should be identified.
Abstract |
PPT 1.8MB. Download.
PDF 1.0MB. Download. |
October 2007 |
Advanced Uses of Freeze-Drying Microscopy for Product Formulation and Lyo-Cycle Development |
Presentation. |
PPT 12.6MB. Download.
PDF 3.0MB. Download. |
June 2007 |
Electrical Impedance Analysis of Nutraceutical Formulation Stability in the Frozen State |
Presentation. Downloads from www.HealthLinks-Events.co.uk. |
PDF, 363KB.
Download |
December 2003 |
Development of a freeze-drying protocol for model protein Lactate Dehydrogenase |
Objectives: To use a range of thermal and analytical techniques to evaluate the applicability
of a range of excipient formulations containing lactate dehydrogenase; To determine whether any correlation exists
between the key parameters determined by these methods with respect to freeze-drying behaviour and final product
qualities. |
PPT 2.8MB. Download.
PDF 194KB. Download. |
September 2003 |
An investigation using thermal and microscopic analysis to determine an optimal freeze-drying
protocol for lyophilized proteins |
The aim of this study was to evaluate the pre- and post- lyophilisation properties of a large series of
protein-excipient combinations using different analysis methods. The success of these mixtures were evaluated on the basis of retained
protein activity and other qualitative and quantitative analyses. |
PPT 2.8MB. Download.
PDF 166KB. Download. |
August 2003 |
Rationalising the freeze-drying of protein formulations: Comparison of a series of pre- and post-
lyophilisation properties |
The aim of the study was to evaluate the pre- and post- lyophilisation properties of a large series of
protein-excipient combinations and to evaulate them on the basis of retained protein activity and other qualitative and
quantitative analyses. |
PPT 3.1MB. Download.
PDF 257KB. Download. |